Estrovera 90 Tablets

Within 4 weeks, ERr 731™ can improve 11 perimenopause symptoms by 14% to 28%, including, poor sleep, irritability, fatigue, sore joints and vaginal dryness.1 After 12 weeks of ERr 731™ use, perimenopausal symptoms were shown to improve by 45% to 78%.1,2

Yes, Estrovera® is a hormone-free plant extract from the root of Rheum rhaponticum (Siberian rhubarb). This special extract, called ERr 731® contains concentrated plant compounds, which act on specific oestrogen receptors throughout the body which helps to relieve menopausal symptoms.​  It is found safe in both animal studies and clinical trials.​3-5 

ERr 731™ gently mimics the effects of oestrogen on a specific receptor found throughout the body, called oestrogen receptor beta. This helps to balance the effects of fluctuating oestrogen levels during perimenopause without altering the body's natural hormone levels.3-6

Low oestrogen levels can increase the activity of enzymes that accelerate the breakdown of feel-good brain chemicals, which can lead to mood changes. By gently stimulating oestrogen receptors, ERr 731™ limits the activity of these enzymes, which can support mood symptoms.7

Stopping Estrovera® may result in symptoms returning although women may safely resume taking. However, symptoms may not reappear if a woman has completed her menopausal transition.

Whilst Estrovera® is shown to help most women, around 10% report no improvement. This may be due to other existing health concerns, or the effects of diet, exercise, lifestyle or stress overriding the soothing benefits of Estrovera®. For more personalised insights, please see your healthcare professional to assess if Estrovera® is right for you.

To ensure Estrovera® is right for you, please discuss with your healthcare professional and/or dispensing pharmacist who can advise on any possible interactions with your medications. 

[1] Shah J, Chandanani S, Reddy J, et al. Evaluation of the efficacy and safety of Rheum rhaponticum Root extract (ERr 731) for menopausal symptoms in perimenopausal Indian women: an interim analysis. J Mid-life Heal. 2021;12(2):108-115. doi:10.4103/jmh.jmh_86_21

[2] Hasper I, Ventskovskiy BM, Rettenberger R, Heger PW, Riley DS, Kaszkin-Bettag M. Long-term efficacy and safety of the special extract ERr 731 of Rheum rhaponticum in perimenopausal women with menopausal symptoms. Menopause. 2009 Jan-Feb;16(1):117-31. doi: 10.1097/GME.0b013e3181806446

[3] Heger M, Ventskovskiy BM, Borzenko I, Kneis KC, Rettenberger R, Kaszkin-Bettag M, et al. Efficacy and safety of a special extract of Rheum rhaponticum (ERr 731) in perimenopausal women with climacteric complaints. Menopause. 2006;13(5):744-759. doi:10.1097/01.gme.0000240632.08182.e4

​[4] Wilson M, Konda V, Heidt K, Rathinasabapathy T, Desai A, Komarnytsky S. Rheum rhaponticum Root Extract Improves Vasomotor Menopausal Symptoms and Estrogen-Regulated Targets in Ovariectomized Rat Model. Int J Mol Sci. 2021;22(3):1032. doi:10.3390/ijms22031032

​[5] Dubey VP, Sureja VP, Kheni DB. Efficacy evaluation of standardized Rheum rhaponticum root extract (ERr 731®) on symptoms of menopause: A systematic review and meta-analysis study. J Biomed Res. 2024;38(3):278-286. doi:10.7555/jbr.37.20230219

[6]Kaszkin-Bettag M. Beck S, Richardson A, Heger PW, Beer AM. Efficacy of the special extract ERr 731 from rhapontic rhubarb for menopausal complaints: a 6-month open observational study. Altern Ther Health Med. 2008 Nov-Dec;14(6):32-38. PMID: 190439363

[7] Wei B, Yang ZD, Shi DF, Yao XJ, Wang MG. Inhibition of monoamine oxidase by stilbenes from Rheum palmatum. Iran J Pharm Res. 2016 Fall;15(4):885-892. PMID: 28243286